Efficacy of venetoclax monotherapy in patients with relapsed, refractory mantle cell lymphoma post BTK inhibitor therapy. See

Mantle cell lymphoma (MCL), an aggressive B-cell malignancy accounting for 6% of non-Hodgkin lymphomas, remains incurable with standard therapy. Despite the approval of bortezomib,1 temsirolimus,2 lenalidomide,3 ibrutinib4 and acalabrutinib,5 patients with relapsed, refractory MCL have a survival of 2 years.

Eyre, TA; Walter, HS; Iyengar, S; Follows, G; Cross, M... et al.

Entropy Analysis of Short-Term Heartbeat Interval Time Series during Regular Walking See

Entropy measures have been extensively used to assess heart rate variability (HRV), a noninvasive marker of cardiovascular autonomic regulation. It is yet to be elucidated whether those entropy measures can sensitively respond to changes of autonomic balance and whether the responses, if there are any, are consistent across different entropy measures. Sixteen healthy subjects were enrolled in this study. Each subject undertook two 5-min ECG measurements, one in a resting seated position ...

Shi, B; Zhang, Y; Yuan, C; Wang, S; Li, P

Glycaemic control and hypoglycaemia burden in patients with type 2 diabetes initiating basal insulin in Europe and the USA See

Aims To evaluate short‐ and long‐term glycaemic control and hypoglycaemia incidence in insulin‐naïve patients ≥30 years of age with type 2 diabetes (T2DM) initiating basal insulin (BI) with or without oral anti‐hyperglycaemic drugs (OADs). Methods This was an observational, retrospective longitudinal analysis of electronic medical records from 5 European countries and the USA. A multivariable logistic regression model assessed baseline and short‐term (0‐3 months post BI initiation) facto...

Mauricio, D; Meneghini, L; Seufert, J; Liao, L; Wang, H... et al.

High-resolution X-Ray Spectroscopy of the Seyfert 1 Galaxy Mrk 1040. Revealing the Failed Nuclear Wind with Chandra See

High-resolution X-ray spectroscopy of the warm absorber in the nearby X-ray bright Seyfert 1 galaxy Mrk 1040 is presented. The observations were carried out in the 2013–2014 timeframe using the Chandra High Energy Transmission Grating with a total exposure of 200 ks. A multitude of absorption lines from Ne, Mg, and Si are detected from a wide variety of ionization states. In particular, the detection of inner K-shell absorption lines from Ne, Mg, and Si, from charge states ranging from F-like...

Reeves, JN; Braito, V; Behar, E; Fischer, TC; Kraemer, SB... et al.

Impacts of Airborne Lidar Pulse Density on Estimating Biomass Stocks and Changes in a Selectively Logged Tropical Forest See

Airborne lidar is a technology well-suited for mapping many forest attributes, including aboveground biomass (AGB) stocks and changes in selective logging in tropical forests. However, trade-offs still exist between lidar pulse density and accuracy of AGB estimates. We assessed the impacts of lidar pulse density on the estimation of AGB stocks and changes using airborne lidar and field plot data in a selectively logged tropical forest located near Paragominas, Pará, Brazil. Field-derived...

Silva, C; Hudak, A; Vierling, L; Klauberg, C; Garcia, M... et al.

Improved classification of leukemic B-cell lymphoproliferative disorders using a transcriptional and genetic classifier. See

B-cell chronic lymphoproliferative disorders (B-CLPD) encompass a group of hematologic tumors that often present with leukemic involvement.1 Their heterogeneity and the lack of relatively specific diagnostic markers for most of these diseases make their diagnosis challenging, especially in cases that only have blood involvement or when histology is not available. With the currently used immunophenotypic and molecular markers, around 10% of B-CLPD cases remain unclassifiable and are categorize...

Navarro, A; Clot, G; Martínez-Trillos, A; Pinyol, M; Jares, P... et al.

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. See

Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10-12). β-Klotho is an obligate coreceptor for the hormone FGF21, which ...

Schumann, G; Liu, C; O'Reilly, P; Gao, H; Song, P... et al.

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study. See

Improvements in immunosuppression have modified short-term survival of deceased-donor allografts, but not their rate of long-term failure. Mismatches between donor and recipient HLA play an important role in the acute and chronic allogeneic immune response against the graft. Perfect matching at clinically relevant HLA loci does not obviate the need for immunosuppression, suggesting that additional genetic variation plays a critical role in both short- and long-term graft outcomes. By combinin...

Hernandez-Fuentes, MP; Franklin, C; Rebollo-Mesa, I; Mollon, J; Delaney, F... et al.

Low activity of lytic pelagiphages in coastal marine waters. See

Phages infect marine bacteria impacting their dynamics, diversity and physiology, but little is known about specific phage-host interactions in situ. We analyzed the joint dynamics in the abundance of phage-related transcripts, as an indicator of viral lytic activity, and their potential hosts using a metatranscriptomic dataset obtained over 2 years in coastal temperate waters of the NE Atlantic. Substantial temporal variability was identified in the expression levels of different phages, lik...

Alonso-Sáez, L; Morán, XAG; Clokie, MR

Nonsyndromic Parkinson disease in a family with autosomal dominant optic atrophy due to OPA1 mutations See

Many genes implicated in familial Parkinson disease (PD) code for proteins with mitochondrial function.1 Several of these genes, including PINK1 and PARK2, are involved in mitophagy, a mitochondrial quality control pathway.2 We describe a family with 3 members affected by autosomal dominant optic atrophy in which 2 affected members also developed PD. While the role of mitophagy-related genes in PD is well established, this report provides further evidence of PD risk conferred through ...

Lynch, DS; Loh, SH; Harley, J; Noyce, AJ; Martins, LM... et al.

Predicting Stem Total and Assortment Volumes in an Industrial Pinus taeda L. Forest Plantation Using Airborne Laser Scanning Data and Random Forest See

Improvements in the management of pine plantations result in multiple industrial and environmental benefits. Remote sensing techniques can dramatically increase the efficiency of plantation management by reducing or replacing time-consuming field sampling. We tested the utility and accuracy of combining field and airborne lidar data with Random Forest, a supervised machine learning algorithm, to estimate stem total and assortment (commercial and pulpwood) volumes in an industrial Pinus taeda ...

Silva, C; Klauberg, C; Hudak, A; Vierling, L; Jaafar, W... et al.

Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis See

Pregabalin, widely used in the treatment of several pain disorders, is usually well tolerated. Uncommonly, the drug may induce cardiac side effects, rarely prolongation of the PR interval. The latter has never been described in patients with healthy heart or normal renal function. We characterize a unique case of a young man with extrapulmonary tuberculosis and no detectable or known cardiac or kidney diseases, treated with pregabalin to control the severe pain due to the involvement of the s...

Schiavo, A; Stagnaro, FM; Salzano, A; Marra, AM; Bobbio, E... et al.

Screening for non-adherence to antihypertensive treatment as a part of the diagnostic pathway to renal denervation. See

Renal denervation is a potential therapeutic option for resistant hypertension. A thorough clinical assessment to exclude reversible/spurious causes of resistance to antihypertensive therapy is required prior to this procedure. The extent to which non-adherence to antihypertensive treatment contributes to apparent resistance to antihypertensive therapy in patients considered for renal denervation is not known. Patients (n=34) referred for renal denervation entered the evaluation pathway that ...

Patel, P; Gupta, PKC; White, CMJ; Stanley, AG; Williams, B... et al.

Structural uncertainty in air mass factor calculation for NO2 and HCHO satellite retrievals See

Air mass factor (AMF) calculation is the largest source of uncertainty in NO2 and HCHO satellite retrievals in situations with enhanced trace gas concentrations in the lower troposphere. Structural uncertainty arises when different retrieval methodologies are applied within the scientific community to the same satellite observations. Here, we address the issue of AMF structural uncertainty via a detailed comparison of AMF calculation methods that are structurally different between seven retri...

Lorente, A; Boersma, KF; Yu, H; Doerner, S; Hilboll, A... et al.

Synthetic minority oversampling technique and fractal dimension for identifying multiple sclerosis See

Multiple sclerosis (MS) is a severe brain disease. Early detection can provide timely treatment. Fractal dimension can provide statistical index of pattern changes with scale at a given brain image. In this study, our team used susceptibility weighted imaging technique to obtain 676 MS slices and 880 healthy slices. We used synthetic minority oversampling technique to process the unbalanced dataset. Then, we used Canny edge detector to extract distinguishing edges. The Minkowski–Bouligand dim...

Zhang, Y-D; Zhang, Y; Phillips, P; Dong, Z; Wang, S

Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development. See

Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1 subunit. The β1 cytoplasmic tail has two NPxY motifs that mediate functions by binding to cytoplasmic signaling and scaffolding molecules. Talins, scaffolding proteins that bind to the membrane proximal NPxY motif, are proposed to activate int...

Mathew, S; Palamuttam, RJ; Mernaugh, G; Ramalingam, H; Lu, Z... et al.

Wavelet Entropy and Directed Acyclic Graph Support Vector Machine for Detection of Patients with Unilateral Hearing Loss in MRI Scanning See

Highlights (1) We develop computer-aided diagnosis system for unilateral hearing loss detection in structural magnetic resonance imaging. (2) Wavelet entropy is introduced to extract image global features from brain images. Directed acyclic graph is employed to endow support vector machine an ability to handle multi-class problems. (3) The developed computer-aided diagnosis system achieves an overall accuracy of 95.1% for this three-class problem of differentiating left-sided and rig...

Wang, S; Yang, M; Du, S; Yang, J; Liu, B... et al.

Soft X-ray Imaging of the Magnetosheath and Cusps Under Different Solar Wind Conditions: MHD Simulations See

The soft X‐ray emissions from the Earth's magnetosheath and cusp regions are simulated under different solar wind conditions, based on the PPMLR‐MHD code. The X‐ray images observed by a hypothetical telescope are presented, and the basic responses of the magnetopause and cusp regions are discernable in these images. From certain viewing geometries, the magnetopause position in the equatorial plane, as well as the latitudinal scales and azimuthal extent of cusp can be directly extracted from t...

Sun, TR; Wang, C; Sembay, SF; Lopez, RE; Escoubet, CP... et al.

Boundary Detection in Three Dimensions With Application to the SMILE Mission: The Effect of Photon Noise See

Imaging magnetospheric satellite missions provide information, which is complementary to in situ observations. Imaging is often able to provide an instantaneous picture of large‐scale structures, whereas in situ measurements, even multipoint in situ measurements, can only provide an average view of large‐scale structure. But imaging also presents some challenges. When three‐dimensional structures need to be extracted from two‐dimensional images, it is necessary to either make suitable assumpt...

Jorgensen, AM; Sung, T; Wang, C; Dai, L; Sembay, S... et al.