[First paragraph] For over a decade the ‘Jodi Awards’ have been celebrating cultural organizations that achieve excellence and push the boundaries of possibility for digital media in increasing participation for everyone. The inaugural awards took place in 2003, the European Year of Disabled People, and today they are administered by the Jodi Mattes Trust, a UK registered charity. The Jodi Awards are given in memory of Jodi Mattes (1973–2001), a tireless champion of equal access to cult...

Parry, Ross

The potential of inexpensive Metal Oxide Semiconductor (MOS) gas sensors to be used for urban air quality monitoring has been the topic of increasing interest in the last decade. This paper discusses some of the lessons of three years of experience working with such sensors on a novel instrument platform (Small Open General purpose Sensor (SOGS)) in the measurement of atmospheric nitrogen dioxide and ozone concentrations. Analytic methods for increasing long-term accuracy of measurements are ...

Peterson, Philip J. D.; Aujla, Amrita; Grant, Kirsty H.; Brundle, Alex G.; Thompson, Martin R.... et al.

Crop yield loss due to flooding is a threat to food security. Submergence-induced hypoxia in plants results in stabilization of group VII ETHYLENE RESPONSE FACTORs (ERF-VIIs), which aid survival under these adverse conditions. ERF-VII stability is controlled by the N-end rule pathway, which proposes that ERF-VII N-terminal cysteine oxidation in normoxia enables arginylation followed by proteasomal degradation. The PLANT CYSTEINE OXIDASEs (PCOs) have been identified as catalysts of this oxidat...

White, Mark D.; Klecker, Maria; Hopkinson, Richard J.; Weits, Daan A.; Mueller, Carolin... et al.

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single n...

Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW... et al.

Finding a balance between observation duration and detection rates is the ultimate goal of the detection of ultra high speed targets. However, short observation durations, both across range unit (ARU) and Doppler frequency migration (DFM), may severely limit the detection performance of ultra high speed targets. Although traditional coherent integration methods can efficiently accumulate signal energy to produce a high signal to noise ratio (SNR) measurement, they often need to search...

Chen, Jun; Wang, Fei; Zhou, Jianjiang; Li, Ling; Crookes, Danny... et al.

Understanding how patterns and travelling waves form in chemical and biological reaction-diffusion models is an area which has been widely researched, yet is still experiencing fast development. Surprisingly enough, we still do not have a clear understanding about all possible types of dynamical regimes in classical reaction-diffusion models, such as Lotka-Volterra competition models with spatial dependence. In this study, we demonstrate some new types of wave propagation and pattern formatio...

Cangiani, Andrea; Georgoulis, Emmanuil H.; Morozov, Andrey Y.; Sutton, O. J.

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlap...

Demenais, F.; Margaritte-Jeannin, P.; Barnes, K. C.; Cookson, W. O. C.; Altmüller, J.... et al.

A modern exhibition should be entertaining and suspense plays a vital role for entertainment media offerings. The lack of research on suspense in museum exhibitions is astonishing. This thesis aims to address this gap by investigating if and how cultural historical exhibitions could be narrated more attractively by adapting scriptwriting techniques used to produce suspense in popular films. A comparative analysis of three classical Hollywood films and three cultural historical exhibitions re...

Karbe, Ariane

This thesis focuses on one north Derbyshire township and its response to industrialization. Wire-drawing was just one of the crafts practiced in the Hope valley but chance played a part in the development of needle-making factories and workshops in the village of Hathersage. The role of chance in the conduct of the business and particularly in its total collapse by the end of the century is discussed. The relationship with the Arrow Valley where needle-making was more enduring and the develop...

Side, Christopher Douglas

Thesis aims to perform appropriate preparatory work for the Raman Laser Spectrometer (RLS) on ExoMars. In order to test the prototype instrumentation it is important to select analogue samples as close as possible to the drill core that ExoMars will analyse. Work with 200 thousand spectra from the first 1000 sols of ChemCam operation on the Mars Science laboratory detected the presence of a basalt – trachybasalt igneous compositional trend, rich in alkali feldspar. These studies informed anal...

Edwards, Peter Henry

Business processes capture the functional requirements of an organisation. Today’s businesses operate in a very dynamic and complex environment. Thus, the suitability of automation techniques depends on their ability to rapidly and reliably react to change. To react to change rapidly, an adaptation process for business processes is required. This will also satisfy better quality of services, evidenced through performance and availability. The adaptation process includes a need to support self...

Allehyani, Budoor Ahmad

The exceptionally preserved Chengjiang Biota (Yunnan, China) is significant for understanding the rapid development of complex animal-rich ecosystems during the evolutionary radiation of the Cambrian. However, the ecological signal provided by the fossils captured in this deposit may not reflect accurately the in-life community, with transport and decay of carcasses being the principal processes responsible for potential modification. The principal fossil-bearing interval (Maotianshan Shale M...

Qi, Changshi; Li, Chao; Gabbott, Sarah E.; Ma, Xiaoya; Xie, Luhua... et al.

Six examples of α,α′-bis(arylimino)-2,3:5,6-bis(pentamethylene)pyridine-cobalt(II) chlorides, [2,3:5,6-{C4H8C(NAr)}2C5HN]CoCl2 (Ar = 2-(C5H9)-6-MeC6H3Co1, 2-(C6H11)-6-MeC6H3Co2, 2-(C8H15)-6-MeC6H3Co3, 2-(C5H9)-4,6-Me2C6H2Co4, 2-(C6H11)-4,6-Me2C6H2Co5, 2-(C8H15)-4,6-Me2C6H2Co6), containing N-aryl groups that differ in either the ring size of the ortho-cycloalkyl substituents or the para-R group (R = H, Me), have been synthesized using a one-pot template approach. The molecular structure of Co1...

Suo, Hongyi; Oleynik, Ivan I.; Bariashir, Chantsalnyam; Oleynik, Irina V.; Wang, Zheng... et al.

The current frontline symptomatic treatment for Alzheimer's disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach leads to profound dose-related adverse effects. An alternative strategy is to selectively target muscarinic acetylcholine receptors, particularly the M1 muscarinic acetylcholine receptor (M1 mAChR), which was previously shown to have procognitive activity. However, developing M1 mAChR-selective orthosteric ligands...

Bradley, Sophie J.; Bourgognon, Julie-Myrtille; Sanger, Helen E.; Verity, Nicholas; Mogg, Adrian J.... et al.

The dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower mammals and represents an interesting model of muscle regeneration due to its high cell turnover. The resident satellite cells (the bona fide muscle stem cells) remain poorly characterized. Here we analyzed PC satellite cells with regard to developmental origin and purported function. Lineage tracing shows that they originate in Myf5(+), Pax3/Pax7(+) cell populations. Skin and muscle wounding increased PC m...

Naldaiz-Gastesi, Neia; Goicoechea, María; Alonso-Martín, Sonia; Aiastui, Ana; López-Mayorga, Macarena... et al.

This study presents an analysis of Landsat data to quantify how the deployment of landmines and demining operations in the first national park in Iraq, the Halgurd-Sakran Core Zone (HSCZ) in the Kurdistan region, has altered the vegetation/land cover patterns over 17 years (between 1998 and 2015). Post-war impacts of landmines on land cover fragmentation and degradation in HSCZ are examined using GIS and remote sensing. Landmines fundamentally change the available land use options for local c...

Hamad, Rahel; Kolo, Kamal; Balzter, Heiko

Arid and semi-arid regions have different spectral characteristics from other climatic regions. Therefore, appropriate remotely sensed indicators of land use and land cover types need to be defined for arid and semi-arid lands, as indices developed for other climatic regions may not give plausible results in arid and semi-arid regions. For instance, the normalized difference built-up index (NDBI) and normalized difference bareness index (NDBaI) are unable to distinguish between built-up areas...

Rasul, Azad; Balzter, Heiko; Fage Ibrahim, Gaylan R.; Hameed, Hasan M.; Wheeler, James... et al.

The CORINE land cover maps present the longest series of land cover maps with a consistent class labelling system and date back to 1985. This paper presents the results of the CORINE land cover mapping of the United Kingdom for 2012 and the corresponding land cover change map from 2006 to 2012. It compares the rates of change with those of the preceding land cover change map 2000–2006 and finds that land cover change has become smaller in scale, more diverse in types of change and affects mor...

Cole, B.; Smith, G.; Balzter, Heiko

Air-powder interactions are of practical importance in the production of pharmaceuticals, food and high value added chemicals manufactured using powders. For examples, air-powder effects enable consistent and effective dosing of fine cohesive powders into dies on high productivity rotary presses due to the suction fill effect. A purpose built experimental testing rig was developed and calibrated in order to develop a basic understanding of effect of air pressure on the mass flow rate of fi...

Baserinia, R.; Sinka, I. C.