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Title: Heart Rate Variability Analysis of Normal and Growth Restricted Children
Authors: Aziz, Wajid
Schlindwein, Fernando Soares
Wailoo, Michael P.
Biala, Taher Ali Said
Cardona Rocha, Federico
First Published: 2-Nov-2011
Publisher: Springer Verlag
Citation: Clinical Autonomic Research, 2012, 22 (2), pp. 91-97 (7)
Abstract: Introduction: Intrauterine growth restriction (IUGR) has been associated with an increased risk of cardiovascular disease in later life. The regularity mechanism of cardiovascular system is under the control of autonomic nervous system (ANS). The non-optimal fetal growth may alter the development of the ANS and this appears to persist in later life. The aim of the present work is to analyse the synergic activity of the ANS in normal and growth restricted children. For that purpose, heart rate variability analysis from 24 hour ECG recordings of 70 children between 9 and 10 years old, normal and IUGR was performed using linear and non-linear time series analysis techniques. Conclusion: The HRV parameters showed no significant difference between normal and IUGR children. Low birth weight and its association with development of the cardiovascular system and its control have been extensively studied. In order to investigate the effect of low birth weight on HRV parameters, the IUGR children were further divided into two groups: IUGR-1 (birth weight < 2.50 kg) and IUGR-2 (birth weight ≥ 2.50 kg). The results demonstrated that most of the HRV measures showed significant differences between normal Vs. IUGR-1 as well as IUGR-1 Vs. IUGR-2 groups. The effect of gender on HRV measures was also examined and we noticed that girls had lower HRV than boys.
DOI Link: 10.1007/s10286-011-0149-z
ISSN: 0959-9851
eISSN: 1619-1560
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © Springer-Verlag 2011. Deposited with reference to the publisher's archiving policy available on the SHERPA/RoMEO website. The original publication is available at
Appears in Collections:Published Articles, Dept. of Engineering

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