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Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/11030

Title: Directed Metallisation Using Molecular Recognition Tools
Authors: Dondi, Ruggero
Supervisors: Cullis, Paul
Award date: 1-Aug-2012
Presented at: University of Leicester
Abstract: During this thesis a new infrastructure of methods to template functional materials at specific sites in a DNA architecture using molecular recognition of specific DNA duplexes has been developed. The project focused on the use of naturally occurring duplex DNA and the Tollens’ reaction as a mild source of metal amenable to reduction in the presence of aldehyde functional groups. The advantages of this choice are: 1) The use of naturally-occurring DNA increases modularity; 2) The Tollens’ reagent acts as a mild selective metallising reagent that enables the reduction of metal ions at specific sites along DNA. Molecules such as Pyrrole-Imidazole polyamides were prepared and were tested to determine whether selective metallisation of DNA nano-architectures can be achieved by confining the nucleation and growth of silver nanostructures to defined regions along a DNA duplex.
Links: http://hdl.handle.net/2381/11030
Type: Thesis
Level: Doctoral
Qualification: PhD
Rights: Copyright © the author, 2012
Appears in Collections:Leicester Theses
Theses, Dept. of Chemistry

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2012dondirphd - thesis.pdfThesis10.41 MBAdobe PDFView/Open
2012dondirphd - appendix.pdfAppendix129.27 MBAdobe PDFView/Open
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