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Title: uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium.
Authors: Stewart, CE
Nijmeh, HS
Brightling, CE
Sayers, I
First Published: Jun-2012
Citation: THORAX, 2012, 67 (6), pp. 477-487
Abstract: The asthma-associated gene urokinase plasminogen activator receptor (uPAR) may be involved in epithelial repair and airway remodelling. These processes are not adequately targeted by existing asthma therapies. A fuller understanding of the pathways involved in remodelling may lead to development of new therapeutic opportunities. uPAR expression in the lung epithelium of normal subjects and patients with asthma was investigated and the contribution of uPAR to epithelial wound repair in vitro was studied using primary bronchial epithelial cells (NHBECs).
DOI Link: 10.1136/thoraxjnl-2011-200508
eISSN: 1468-3296
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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