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Title: Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.
Authors: Butler, CA
McQuaid, S
Taggart, CC
Weldon, S
Carter, R
Skibinski, G
Warke, TJ
Choy, DF
McGarvey, LP
Bradding, P
Arron, JR
Heaney, LG
First Published: May-2012
Citation: THORAX, 2012, 67 (5), pp. 392-398
Abstract: Upregulation of glucocorticoid receptor β (GRβ) has been implicated in steroid resistance in severe asthma, although previous studies are conflicting. GRβ has been proposed as a dominant negative isoform of glucocorticoid receptor α (GRα) but it has also been suggested that GRβ can cause steroid resistance via reduced expression of histone deacetylase 2 (HDAC2), a key regulator of steroid responsiveness in the airway.
DOI Link: 10.1136/thoraxjnl-2011-200760
eISSN: 1468-3296
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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