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|Title:||Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.|
|Citation:||THORAX, 2012, 67 (5), pp. 392-398|
|Abstract:||Upregulation of glucocorticoid receptor β (GRβ) has been implicated in steroid resistance in severe asthma, although previous studies are conflicting. GRβ has been proposed as a dominant negative isoform of glucocorticoid receptor α (GRα) but it has also been suggested that GRβ can cause steroid resistance via reduced expression of histone deacetylase 2 (HDAC2), a key regulator of steroid responsiveness in the airway.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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