Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/11244
Title: microRNA-34a regulates neurite outgrowth, spinal morphology, and function.
Authors: Agostini, M
Tucci, P
Steinert, JR
Shalom-Feuerstein, R
Rouleau, M
Aberdam, D
Forsythe, ID
Young, KW
Ventura, A
Concepcion, CP
Han, YC
Candi, E
Knight, RA
Mak, TW
Melino, G
First Published: 27-Dec-2011
Citation: PROC NATL ACAD SCI U S A, 2011, 108 (52), pp. 21099-21104
Abstract: The p53 family member TAp73 is a transcription factor that plays a key role in many biological processes, including neuronal development. In particular, we have shown that p73 drives the expression of miR-34a, but not miR-34b and c, in mouse cortical neurons. miR-34a in turn modulates the expression of synaptic targets including synaptotagmin-1 and syntaxin-1A. Here we show that this axis is retained in mouse ES cells committed to differentiate toward a neurological phenotype. Moreover, overexpression of miR-34a alters hippocampal spinal morphology, and results in electrophysiological changes consistent with a reduction in spinal function. Therefore, the TAp73/miR-34a axis has functional relevance in primary neurons. These data reinforce a role for miR-34a in neuronal development.
DOI Link: 10.1073/pnas.1112063108
eISSN: 1091-6490
Links: http://hdl.handle.net/2381/11244
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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