Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/11625
Title: Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease.
Authors: de Chaldée M
Brochier, C
Van de Vel A
Caudy, N
Luthi-Carter, R
Gaillard, MC
Elalouf, JM
First Published: Feb-2006
Citation: GENOMICS, 2006, 87 (2), pp. 200-207
Abstract: In an initial study, we compared quantitative transcriptome data across mouse brain territories using the serial analysis of gene expression method. Among the novel regional markers that we discovered, we focused on a striatum-enriched transcript with no available experimental cDNA sequence. Here, we report its cloning, gene structure, and detailed distribution in mouse brain. Quantitative RT-PCR and in situ hybridization demonstrated predominant expression in dorsolateral striatum. We therefore named it capucin for caudate-and putamen-enriched sequence. Mouse capucin is a 237-amino-acid protein, without any registered ortholog in mammalian species. It contains no recognizable motif other than two predicted carboxy-terminal transmembrane domains. When expressed in fusion with a fluorescent protein, it localized to the Golgi apparatus in two mammalian cell lines. Interestingly, we observed a significant down-regulation of capucin mRNA levels in two rodent models of Huntington disease, indicating a possible contribution to the pathogenesis of this disorder.
DOI Link: 10.1016/j.ygeno.2005.10.009
ISSN: 0888-7543
Links: http://hdl.handle.net/2381/11625
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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