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Title: Biological and potential therapeutic roles of sirtuin deacetylases.
Authors: Taylor, DM
Maxwell, MM
Luthi-Carter, R
Kazantsev, AG
First Published: Dec-2008
Citation: CELL MOL LIFE SCI, 2008, 65 (24), pp. 4000-4018
Abstract: Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases that target multiple protein substrates to execute diverse biological functions. These enzymes are key regulators of clinically important cellular and organismal processes, including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in less than a decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has further catapulted them to a prominent status as potential targets for nutritional and therapeutic development. Here, we present a review of published results on sirtuin biology and its relevance to human disease.
DOI Link: 10.1007/s00018-008-8357-y
eISSN: 1420-9071
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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