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Title: Sustained effects of nonallele-specific Huntingtin silencing.
Authors: Drouet, V
Perrin, V
Hassig, R
Dufour, N
Auregan, G
Alves, S
Bonvento, G
Brouillet, E
Luthi-Carter, R
Hantraye, P
Déglon, N
First Published: Mar-2009
Citation: ANN NEUROL, 2009, 65 (3), pp. 276-285
Abstract: Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. No cure is available to date to alleviate neurodegeneration. Recent studies have demonstrated that RNA interference represents a promising approach for the treatment of autosomal dominant disorders. But whether an allele-specific silencing of mutant htt or a nonallele-specific silencing should be considered has not been addressed.
DOI Link: 10.1002/ana.21569
eISSN: 1531-8249
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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