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|Title:||Sustained effects of nonallele-specific Huntingtin silencing.|
|Citation:||ANN NEUROL, 2009, 65 (3), pp. 276-285|
|Abstract:||Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. No cure is available to date to alleviate neurodegeneration. Recent studies have demonstrated that RNA interference represents a promising approach for the treatment of autosomal dominant disorders. But whether an allele-specific silencing of mutant htt or a nonallele-specific silencing should be considered has not been addressed.|
|Appears in Collections:||Published Articles, Dept. of Cell Physiology and Pharmacology|
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