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Title: What have we learned from gene expression profiles in Huntington's disease?
Authors: Seredenina, Tamara
Luthi-Carter, Ruth
First Published: 12-Jul-2011
Citation: Neurobiology of Disease, 2012, 45 (1), pp. 83–98
Abstract: The availability of many high-quality genome-wide expression datasets has provided an exciting and unique opportunity to better understand the molecular etiology of Huntington's disease. Combining this knowledge with other aspects of huntingtin biology and disease modification screens is yielding important new insights into disease-mitigating therapeutic strategies. Having followed this line of inquiry for some time, we note that there have been a number of surprises regarding the subsequently confirmed relationships between gene expression and disease etiology. Moreover, the complexity and sheer number of proposed mechanisms by which huntingtin can perturb gene expression continues to expand. Nonetheless, ongoing efforts to enthusiastically and critically evaluate the relationships between HD pathobiology and gene expression promise to deliver accurate predictions as to which therapeutic strategies will be most effective. An exciting new arm of this research also demonstrates the power of pharmacogenomics to detect (and rule out) important neuroprotective gene expression effects.
DOI Link: 10.1016/j.nbd.2011.07.001
ISSN: 0969-9961
eISSN: 1095-953X
Type: Journal Article
Description: Full text of this item is not currently available on the LRA. The final published version is available through the links above.
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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