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Title: Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain
Authors: Kuhn, Alexandre
Thu, Doris
Waldvogel, Henry J.
Faull, Richard L.M.
Luthi-Carter, Ruth
First Published: 9-Oct-2011
Citation: Nature Methods, 2001, 8 (11), pp. 945–947
Abstract: Human diseases are often accompanied by histological changes that confound interpretation of molecular analyses and identification of disease-related effects. We developed population-specific expression analysis (PSEA), a computational method of analyzing gene expression in samples of varying composition that can improve analyses of quantitative molecular data in many biological contexts. PSEA of brains from individuals with Huntington's disease revealed myelin-related abnormalities that were undetected using standard differential expression analysis.
DOI Link: 10.1038/nmeth.1710
ISSN: 1548-7091
eISSN: 1548-7105
Type: Journal Article
Description: Full text of this item is not currently available on the LRA. The final published version may be available through the links above.
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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