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|Title:||Synthesis of α-fluoro-β-hydroxy esters by an enantioselective Reformatsky-type reaction.|
|Citation:||CHEM COMMUN (CAMB), 2012, 48 (29), pp. 3500-3502|
|Abstract:||The first enantioselective Reformatsky-type reaction of ethyl iodofluoroacetate has been accomplished with alkyl aryl ketones. High diastereoselectivities and excellent enantioselectivities for the major diastereomer (93-95% ee) were achieved with large alkyl groups. For smaller alkyl groups the diastereoselectivities were moderate, but excellent enantioselectivities were obtained for both diastereomers (79-94% ee).|
|Appears in Collections:||Published Articles, Dept. of Chemistry|
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