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Title: Synthesis of α-fluoro-β-hydroxy esters by an enantioselective Reformatsky-type reaction.
Authors: Fornalczyk, M
Singh, K
Stuart, AM
First Published: 11-Apr-2012
Citation: CHEM COMMUN (CAMB), 2012, 48 (29), pp. 3500-3502
Abstract: The first enantioselective Reformatsky-type reaction of ethyl iodofluoroacetate has been accomplished with alkyl aryl ketones. High diastereoselectivities and excellent enantioselectivities for the major diastereomer (93-95% ee) were achieved with large alkyl groups. For smaller alkyl groups the diastereoselectivities were moderate, but excellent enantioselectivities were obtained for both diastereomers (79-94% ee).
DOI Link: 10.1039/c2cc17985g
eISSN: 1364-548X
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Chemistry

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