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Title: A shift in the Bax/Bcl-2 balance may activate caspase-3 and modulate apoptosis in experimental glomerulonephritis.
Authors: Yang, B
Johnson, TS
Thomas, GL
Watson, PF
Wagner, B
Furness, PN
El Nahas AM
First Published: Oct-2002
Citation: KIDNEY INT, 2002, 62 (4), pp. 1301-1313
Abstract: Although apoptosis has been linked to the renal cell deletion and ensuing renal fibrosis, its regulating mechanisms remain obscure. Of the known regulators of apoptosis, the best characterized is the Bax to Bcl-2 ratio. However, its importance in controlling apoptosis in glomerulonephritis is unclear. Here, using the nephrotoxic nephritis (NTN) model, we evaluated Bax/Bcl-2 in relation to changes in the apoptosis co-ordination enzyme, caspase-3.
DOI Link: 10.1111/j.1523-1755.2002.kid587.x
ISSN: 0085-2538
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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