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Title: Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.
Authors: Ferland-McCollough, D
Fernandez-Twinn, DS
Cannell, IG
David, H
Warner, M
Vaag, AA
Bork-Jensen, J
Brøns, C
Gant, TW
Willis, AE
Siddle, K
Bushell, M
Ozanne, SE
First Published: Jun-2012
Citation: CELL DEATH DIFFER, 2012, 19 (6), pp. 1003-1012
Abstract: Nutrition during early mammalian development permanently influences health of the adult, including increasing the risk of type 2 diabetes and coronary heart disease. However, the molecular mechanisms underlying such programming are poorly defined. Here we demonstrate that programmed changes in miRNA expression link early-life nutrition to long-term health. Specifically, we show that miR-483-3p is upregulated in adipose tissue from low-birth-weight adult humans and prediabetic adult rats exposed to suboptimal nutrition in early life. We demonstrate that manipulation of miR-483-3p levels in vitro substantially modulates the capacity of adipocytes to differentiate and store lipids. We show that some of these effects are mediated by translational repression of growth/differentiation factor-3, a target of miR-483-3p. We propose that increased miR-483-3p expression in vivo, programmed by early-life nutrition, limits storage of lipids in adipose tissue, causing lipotoxicity and insulin resistance and thus increasing susceptibility to metabolic disease.
DOI Link: 10.1038/cdd.2011.183
eISSN: 1476-5403
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biochemistry

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