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Title: Oxidative and non-oxidative DNA damage and cardiovascular disease.
Authors: Malik, Q
Herbert, KE
First Published: Apr-2012
Citation: FREE RADIC RES, 2012, 46 (4), pp. 554-564
Abstract: Evidence for the association of DNA damage with cardiovascular disease has been obtained from in vitro cell culture models, experimental cardiovascular disease and analysis of samples obtained from humans with disease. There is general acceptance that several factors associated with the risk of developing cardiovascular disease cause oxidative damage to DNA in cell culture models with both nuclear and mitochondrial DNA as targets. Moreover, evidence obtained over the past 10 years points to a possible mechanistic role for DNA damage in experimental atherosclerosis culminating in recent studies challenging the assumption that DNA damage is merely a biomarker of the disease process. This kind of mechanistic insight provides a renewed impetus for further studies in this area.
DOI Link: 10.3109/10715762.2012.663913
eISSN: 1029-2470
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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