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Title: The relationship between clinical outcomes and medication adherence in difficult-to-control asthma.
Authors: Murphy, AC
Proeschal, A
Brightling, CE
Wardlaw, AJ
Pavord, I
Bradding, P
Green, RH
First Published: Aug-2012
Citation: THORAX, 2012, 67 (8), pp. 751-753
Abstract: Medication non-adherence and the clinical implications in difficult-to-control asthma were audited. Prescription issue data from 115 patients identified sub-optimal adherence (<80%) in 65% of patients on inhaled corticosteroids (ICS) or combined ICS/long-acting β2 agonist (LABA). In those using separate ICS and LABA, adherence to LABA (50%) was significantly better than to ICS (14.3%). Patients with sub-optimal ICS adherence had reduced FEV(1) and higher sputum eosinophil counts. Adherence ratio was an independent predictor of previous ventilation for acute severe asthma (p=0.008). The majority of patients with difficult-to-control asthma are non-adherent with their asthma medication. Non-adherence is correlated with poor clinical outcomes.
DOI Link: 10.1136/thoraxjnl-2011-201096
eISSN: 1468-3296
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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