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|Title:||Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2 : structure−activity relationship, structural biology, and cellular activity|
Cheung, Kwai-Ming J.
Baxter, Joanne E.
Aherne, G. Wynne
Fry, Andrew M.
|Publisher:||American Chemical Society|
|Citation:||Journal of Medicinal Chemistry, 2012, 55 (7), pp. 3228–3241|
|Abstract:||We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. Structure based design led to aminopyridine (R)-21, a potent and selective inhibitor able to modulate Nek2 activity in cells.|
|Rights:||Copyright © 2012 American Chemical Society. All rights reserved. Deposited with reference to the publisher’s open access archiving policy.|
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jm201683b.
|Appears in Collections:||Published Articles, Dept. of Biochemistry|
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