Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/12608
Title: Structural and dynamic aspects of Ca2+ and Mg2+ binding of the regulatory domains of the Na+/Ca2+ exchanger.
Authors: Breukels, V
Touw, WG
Vuister, GW
First Published: Apr-2012
Citation: BIOCHEM SOC TRANS, 2012, 40 (2), pp. 409-414
Abstract: Intracellular Ca2+ regulates the activity of the NCX (Na+/Ca2+ exchanger) through binding to the cytosolic CBD (Ca2+-binding domain) 1 and CBD2. In vitro studies of the structure and dynamics of CBD1 and CBD2, as well as studies of their kinetics and thermodynamics of Ca2+ binding, greatly enhanced our understanding of NCX regulation. We describe the fold of the CBDs in relation to other known structures and review Ca2+ binding of the different CBD variants from a structural perspective. We also report on new findings concerning Mg2+ binding to the CBDs and finally we discuss recent results on CBD1-CBD2 interdomain interactions.
DOI Link: 10.1042/BST20110742
eISSN: 1470-8752
Links: http://hdl.handle.net/2381/12608
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biochemistry

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