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|Title:||Inflammatory and Satellite Cells in the Quadriceps of Patients with COPD and the Response to Resistance Training.|
|Abstract:||ABSTRACT BACKGROUND:Quadriceps dysfunction in COPD may be mediated by inflammatory mechanisms or impaired satellite cell function. Resistance training is of proven efficacy in these patients, but data on muscle inflammatory and satellite cell response to resistance exercise in COPD is lacking. We aimed to examine the inflammatory and satellite cell profile of the quadriceps in COPD patients and healthy controls at rest and after acute and chronic resistance exercise. METHODS:17 COPD patients and 10 healthy controls underwent 8 weeks of bilateral lower-limb, high-intensity resistance training, thrice weekly, on an isokinetic dynamometer. Quadriceps muscle biopsies from the dominant thigh were obtained at baseline, 24 hours following the first exercise bout, and after 8 weeks, 24 hours after the last exercise bout. Glycol methacrylate-embedded muscle biopsies were analysed using immunohistochemistry to identify neutrophils, macrophages and satellite cells. RESULTS:Neutrophils were significantly elevated in the quadriceps of COPD patients at baseline compared to healthy controls (p = 0.03). Inflammatory cells were increased significantly at 24 hours in both groups, but similar to baseline values at week 8, with no difference detectable between health and COPD. Satellite cell numbers were comparable between patients and controls at baseline, tended to increase at 24 hours, and remained elevated at week 8. CONCLUSIONS:Inflammatory cells are elevated in the resting quadriceps of COPD patients. Acute resistance exercise leads to an inflammatory myositis, which is attenuated with regular training. Satellite cells in patients and controls are comparable, and are increased in response to exercise.Trial registration: www.controlled-trials.com (Identifier: ISRCTN22764439).|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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