Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/13033
Title: Asymmetric synthesis of 3-amino-4-hydroxy-2-(hydroxymethyl)pyrrolidines as potential glycosidase inhibitors.
Authors: Curtis, KL
Evinson, EL
Handa, S
Singh, K
First Published: 7-Nov-2007
Citation: ORG BIOMOL CHEM, 2007, 5 (21), pp. 3544-3553
Abstract: Three diastereoisomers of 3-amino-4-hydroxy-2-(hydroxymethyl)pyrrolidine have been synthesised by a divergent route starting from trans-4-hydroxy-L-proline. Regio- and stereoselective introduction of the 3-amino and 4-hydroxyl functional groups was achieved using either a tethered aminohydroxylation reaction or by employing intra- and intermolecular epoxide-opening strategies. Preliminary biological data indicate that two of these novel amino pyrrolidines are moderate inhibitors of beta-galactosidase.
DOI Link: 10.1039/b711994a
ISSN: 1477-0520
Links: http://hdl.handle.net/2381/13033
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Chemistry

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