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Title: Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development.
Authors: Karmokar, A
Marczylo, TH
Cai, H
Steward, WP
Gescher, AJ
Brown, K
First Published: May-2012
Citation: MOL NUTR FOOD RES, 2012, 56 (5), pp. 775-783
Abstract: Rosmarinic acid (RA), a constituent of culinary herbs is considered to possess cancer chemopreventive properties. It has been shown to inhibit the development of cancer in preclinical models but data are conflicting and whether it can protect against gastrointestinal malignancies in vivo has not been examined. This study aimed to investigate the effect of RA on the development of intestinal adenomas in the Apc(Min) mouse model of colorectal carcinogenesis, and to correlate efficacy with levels of RA achieved in the plasma and gastrointestinal tract.
DOI Link: 10.1002/mnfr.201100617
eISSN: 1613-4133
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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