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Title: Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains
Authors: Grills, C.
Crawford, N.
Chacko, A.
Johnston, P. G.
O'Rourke, F.
Fennell, D. A.
First Published: 22-Aug-2008
Publisher: Public Library of Science
Citation: PLOS ONE, 2008, 3 (8), p. e3038
Abstract: The molecular mechanism underlying mitochondrial BAK activation during apoptosis remains highly controversial. Two seemingly conflicting models have been proposed. In one, BAK requires so-called activating BH3 only proteins (aBH3) to initiate its conformation change. In the other, displacement from inhibitory pro-survival BCL-2 proteins (PBPs) and monomerization of BAK by PBP selective dissociator BH3-only proteins (dBH3) is sufficient.
DOI Link: 10.1371/journal.pone.0003038
eISSN: 1932-6203
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2008 Grills et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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