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|Title:||Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains|
Johnston, P. G.
Fennell, D. A.
|Publisher:||Public Library of Science|
|Citation:||PLOS ONE, 2008, 3 (8), p. e3038|
|Abstract:||The molecular mechanism underlying mitochondrial BAK activation during apoptosis remains highly controversial. Two seemingly conflicting models have been proposed. In one, BAK requires so-called activating BH3 only proteins (aBH3) to initiate its conformation change. In the other, displacement from inhibitory pro-survival BCL-2 proteins (PBPs) and monomerization of BAK by PBP selective dissociator BH3-only proteins (dBH3) is sufficient.|
|Rights:||Copyright © 2008 Grills et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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