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|Title:||Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8.|
|Citation:||BMC CANCER, 2010, 10, pp. 380-380|
|Abstract:||Activation of the extrinsic apoptosis pathway by tumour necrosis factor related apoptosis inducing ligand (TRAIL) is a novel therapeutic strategy for treating cancer that is currently under clinical evaluation. Identification of molecular biomarkers of resistance is likely to play an important role in predicting clinical anti tumour activity. The involvement of the mitochondrial type 1 voltage dependent anion channel (VDAC1) in regulating apoptosis has been highly debated. To date, a functional role in regulating the extrinsic apoptosis pathway has not been formally excluded.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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