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|Title:||A TMA de-arraying method for high throughput biomarker discovery in tissue research.|
James, J. A.
Fennell, D. A.
Hamilton, P. W.
|Publisher:||Public Library of Science|
|Citation:||PLOS ONE, 2011, 6 (10), p. e26007|
|Abstract:||Tissue MicroArrays (TMAs) represent a potential high-throughput platform for the analysis and discovery of tissue biomarkers. As TMA slides are produced manually and subject to processing and sectioning artefacts, the layout of TMA cores on the final slide and subsequent digital scan (TMA digital slide) is often disturbed making it difficult to associate cores with their original position in the planned TMA map. Additionally, the individual cores can be greatly altered and contain numerous irregularities such as missing cores, grid rotation and stretching. These factors demand the development of a robust method for de-arraying TMAs which identifies each TMA core, and assigns them to their appropriate coordinates on the constructed TMA slide.|
|Rights:||Copyright © 2011 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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