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Title: Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.
Authors: WHO Collaborating Center for Asthma and Rhinitis
Bousquet, J
Anto, JM
Demoly, P
Schünemann, HJ
Togias, A
Akdis, M
Auffray, C
Bachert, C
Bieber, T
Bousquet, PJ
Carlsen, KH
Casale, TB
Cruz, AA
Keil, T
Lodrup Carlsen KC
Maurer, M
Ohta, K
Papadopoulos, NG
Roman Rodriguez M
Samolinski, B
Agache, I
Andrianarisoa, A
Ang, CS
Annesi-Maesano, I
Ballester, F
Baena-Cagnani, CE
Basagaña, X
Bateman, ED
Bel, EH
Bedbrook, A
Beghé, B
Beji, M
Ben Kheder A
Benet, M
Bennoor, KS
Bergmann, KC
Berrissoul, F
Bindslev Jensen C
Bleecker, ER
Bonini, S
Boner, AL
Boulet, LP
Brightling, CE
Brozek, JL
Bush, A
Busse, WW
Camargos, PA
Canonica, GW
Carr, W
Cesario, A
Chen, YZ
Chiriac, AM
Costa, DJ
Cox, L
Custovic, A
Dahl, R
Darsow, U
Didi, T
Dolen, WK
Douagui, H
Dubakiene, R
El-Meziane, A
Fonseca, JA
Fokkens, WJ
Fthenou, E
Gamkrelidze, A
Garcia-Aymerich, J
Gerth van Wijk R
Gimeno-Santos, E
Guerra, S
Haahtela, T
Haddad, H
Hellings, PW
Hellquist-Dahl, B
Hohmann, C
Howarth, P
Hourihane, JO
Humbert, M
Jacquemin, B
Just, J
Kalayci, O
Kaliner, MA
Kauffmann, F
Kerkhof, M
Khayat, G
Koffi N'Goran B
Kogevinas, M
Koppelman, GH
Kowalski, ML
Kull, I
Kuna, P
Larenas, D
Lavi, I
Le, LT
Lieberman, P
Lipworth, B
Mahboub, B
Makela, MJ
Martin, F
Martinez, FD
Marshall, GD
Mazon, A
Melen, E
Meltzer, EO
Mihaltan, F
Mohammad, Y
Mohammadi, A
Momas, I
Morais-Almeida, M
Mullol, J
Muraro, A
Naclerio, R
Nafti, S
Namazova-Baranova, L
Nawijn, MC
Nyembue, TD
Oddie, S
O'Hehir, RE
Okamoto, Y
Orru, MP
Ozdemir, C
Ouedraogo, GS
Palkonen, S
Panzner, P
Passalacqua, G
Pawankar, R
Pigearias, B
Pin, I
Pinart, M
Pison, C
Popov, TA
Porta, D
Postma, DS
Price, D
Rabe, KF
Ratomaharo, J
Reitamo, S
Rezagui, D
Ring, J
Roberts, R
Roca, J
Rogala, B
Romano, A
Rosado-Pinto, J
Ryan, D
Sanchez-Borges, M
Scadding, GK
Sheikh, A
Simons, FE
Siroux, V
Schmid-Grendelmeier, PD
Smit, HA
Sooronbaev, T
Stein, RT
Sterk, PJ
Sunyer, J
Terreehorst, I
Toskala, E
Tremblay, Y
Valenta, R
Valeyre, D
Vandenplas, O
van Weel C
Vassilaki, M
Varraso, R
Viegi, G
Wang, DY
Wickman, M
Williams, D
Wöhrl, S
Wright, J
Yorgancioglu, A
Yusuf, OM
Zar, HJ
Zernotti, ME
Zidarn, M
Zhong, N
Zuberbier, T
First Published: 2012
Citation: INT ARCH ALLERGY IMMUNOL, 2012, 158 (3), pp. 216-231
Abstract: Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
DOI Link: 10.1159/000332924
eISSN: 1423-0097
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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