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|Title:||Endotoxaemia in haemodialysis: a novel factor in erythropoetin resistance?|
|Authors:||Harrison, L. E.|
Burton, J. O.
Szeto, C. C.
Li, P. K.
McIntyre, C. W.
|Publisher:||Public Library of Science|
|Citation:||PLOS ONE, 2012, 7 (6), p. e40209|
|Abstract:||Translocated endotoxin derived from intestinal bacteria is a driver of systemic inflammation and oxidative stress. Severe endotoxaemia is an underappreciated, but characteristic finding in haemodialysis (HD) patients, and appears to be driven by acute repetitive dialysis induced circulatory stress. Resistance to erythropoietin (EPO) has been identified as a predictor of mortality risk, and associated with inflammation and malnutrition. This study aims to explore the potential link between previously unrecognised endotoxaemia and EPO Resistance Index (ERI) in HD patients.|
|Rights:||Copyright © 2012 Harrison et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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