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Title: The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration
Authors: Burrows, C.
Latip, N. A.
Lam, S-J.
Carpenter, L.
Sawicka, K.
Tzolovsky, G.
Gabra, H.
Bushell, M.
Glover, D. M.
Willis, A. E.
Blagden, S. P.
First Published: 29-Apr-2010
Publisher: Oxford University Press
Citation: Nucleic Acids Research, 2010, 38 (16), pp. 5542-5553
Abstract: The RNA binding protein Larp1 was originally shown to be involved in spermatogenesis, embryogenesis and cell-cycle progression in Drosophila. Our data show that mammalian Larp1 is found in a complex with poly A binding protein and eukaryote initiation factor 4E and is associated with 60S and 80S ribosomal subunits. A reduction in Larp1 expression by siRNA inhibits global protein synthesis rates and results in mitotic arrest and delayed cell migration. Consistent with these data we show that Larp1 protein is present at the leading edge of migrating cells and interacts directly with cytoskeletal components. Taken together, these data suggest a role for Larp1 in facilitating the synthesis of proteins required for cellular remodelling and migration.
DOI Link: 10.1093/nar/gkq294
ISSN: 0305-1048
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © The Author(s) 2010. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Biochemistry

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