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|Title:||Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.|
Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) Study Group
|Citation:||J ALLERGY CLIN IMMUNOL, 2012, 130 (3), pp. 647-6.54E+12|
|Abstract:||Eosinophilic airway inflammation is heterogeneous in asthmatic patients. We recently described a distinct subtype of asthma defined by the expression of genes inducible by T(H)2 cytokines in bronchial epithelium. This gene signature, which includes periostin, is present in approximately half of asthmatic patients and correlates with eosinophilic airway inflammation. However, identification of this subtype depends on invasive airway sampling, and hence noninvasive biomarkers of this phenotype are desirable.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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