Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/13728
Title: Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
Authors: Jia, G
Erickson, RW
Choy, DF
Mosesova, S
Wu, LC
Solberg, OD
Shikotra, A
Carter, R
Audusseau, S
Hamid, Q
Bradding, P
Fahy, JV
Woodruff, PG
Harris, JM
Arron, JR
Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) Study Group
First Published: Sep-2012
Citation: J ALLERGY CLIN IMMUNOL, 2012, 130 (3), pp. 647-6.54E+12
Abstract: Eosinophilic airway inflammation is heterogeneous in asthmatic patients. We recently described a distinct subtype of asthma defined by the expression of genes inducible by T(H)2 cytokines in bronchial epithelium. This gene signature, which includes periostin, is present in approximately half of asthmatic patients and correlates with eosinophilic airway inflammation. However, identification of this subtype depends on invasive airway sampling, and hence noninvasive biomarkers of this phenotype are desirable.
DOI Link: 10.1016/j.jaci.2012.06.025
eISSN: 1097-6825
Links: http://hdl.handle.net/2381/13728
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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