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Title: An RNA Splicing Enhancer that Does Not Act by Looping.
Authors: Lewis, H
Perrett, AJ
Burley, GA
Eperon, IC
First Published: 24-Sep-2012
Citation: ANGEW CHEM INT ED ENGL, 2012, 51 (39), pp. 9800-9803
Abstract: Out of the loop: Do the proteins bound to an enhancer site on pre-mRNA interact directly with the splice site by diffusion (looping), as is generally accepted, or does the intervening RNA play a role? By inserting a PEG linker between an enhancer sequence and alternative splice sites, the interaction of these two elements can be studied. Intervening RNA was essential for the enhancer activity, which rules out the looping model.
DOI Link: 10.1002/anie.201202932
eISSN: 1521-3773
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biochemistry

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