Please use this identifier to cite or link to this item:
Title: Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer.
Authors: Fennell, Dean A.
Swanton, C.
First Published: 18-Jun-2012
Publisher: BioMed Central for European Association for Predictive, Preventive and Personalised Medicine, Springer Verlag (Germany)
Citation: EPMA Journal, 2012, 3 (1), pp. 6-6
Abstract: ABSTRACT: Evasion of apoptosis is a hallmark of tumorigenesis and a recognised cause of multidrug resistance. Over the last decade, insights into how apoptosis might be exploited in non-small cell lung cancer (NSCLC) and how cancer therapeutics might be used to engage apoptotic signalling in a personalised manner have changed markedly. We are now in the wake of a paradigm shift in stratified therapeutic approaches related to NSCLC. At the heart of this shift in thinking is the emerging knowledge that even the most drug-resistant cancers exhibit a functional death pathway and, critically, that this pathway can be efficiently engaged, leading to clinical benefit. This review will summarise current knowledge of mitochondrial apoptotic pathway dysfunction in NSCLC and how the next generation of targeted therapeutics might be used to exploit deficiencies in apoptotic signalling in a personalised manner to improve clinical outcome and predict therapeutic benefit.
DOI Link: 10.1186/1878-5085-3-6
ISSN: 1878-5077
eISSN: 1878-5085
Type: Journal Article
Rights: © Fennell and Swanton; licensee BioMed Central Ltd. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

Files in This Item:
File Description SizeFormat 
art%3A10.1186%2F1878-5085-3-6.pdfPublisher version426.83 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.