Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/14185
Title: MADS-complexes regulate transcriptome dynamics during pollen maturation.
Authors: Verelst, W.
Twell, David
de Folter S.
Immink, Richard
Saedler, H.
Münster, T.
First Published: 22-Nov-2007
Publisher: BioMed Central
Citation: Genome Biology, 2007, 8 (11), pp. R249-R249
Abstract: Differentiation processes are responsible for the diversity and functional specialization of the cell types that compose an organism. The outcome of these processes can be studied at molecular, physiologic, and biochemical levels by comparing different cell types, but the complexity and dynamics of the regulatory processes that specify the differentiation are largely unexplored.
Background Differentiation processes are responsible for the diversity and functional specialization of the cell types that compose an organism. The outcome of these processes can be studied at molecular, physiologic, and biochemical levels by comparing different cell types, but the complexity and dynamics of the regulatory processes that specify the differentiation are largely unexplored. Results Here we identified the pollen-specific MIKC* class of MADS-domain transcription factors as major regulators of transcriptome dynamics during male reproductive cell development in Arabidopsis thaliana. Pollen transcript profiling of mutants deficient in different MIKC* protein complexes revealed that they control a transcriptional switch that directs pollen maturation and that is essential for pollen competitive ability. We resolved the functional redundancy among the MIKC* proteins and uncovered part of the underlying network by identifying the non-MIKC* MADS-box genes AGL18 and AGL29 as downstream regulators of a subset of the MIKC* MADS-controlled genes. Conclusion Our results provide a first, unique, and compelling insight into the complexity of a transcription factor network that directs cellular differentiation during pollen maturation, a process that is essential for male reproductive fitness in flowering plants.
DOI Link: 10.1186/gb-2007-8-11-r249
eISSN: 1465-6914
Links: http://hdl.handle.net/2381/14185
http://genomebiology.com/content/8/11/R249
Type: Journal Article
Rights: © 2007 Verelst et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Biology

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