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|Title:||Analysis of the mammalian talin2 gene TLN2.|
|Citation:||BIOCHEM BIOPHYS RES COMMUN, 2001, 286 (5), pp. 880-885|
|Abstract:||We have utilised genomic and EST databases to assemble the sequence of the human talin2 (TLN2) gene. Talin2 protein is similar in size and sequence to talin1 throughout its length (74% identity, 86% similarity). The major differences are in (i) the size of the genes, the TLN2 gene is >200 kb compared with approximately 30 kb for TLN1 due to a difference in intron size, although intron/exon boundaries, with the exception of two, are strictly conserved; (ii) the expression patterns, TLN1 gives rise to an approximately 8-kb mRNA which is observed in all tissues, whereas TLN2 gives rise to multiple transcripts with the highest levels in heart.|
|Appears in Collections:||Published Articles, Dept. of Biochemistry|
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