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|Title:||Sealed with a Kiz: How Plk1 ensures spindle pole integrity.|
|Citation:||DEV CELL, 2006, 11 (4), pp. 431-432|
|Abstract:||The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of Kiz ensures the integrity of spindle poles in the face of severe pulling forces exerted by the chromosome-attached spindle microtubules.|
|Appears in Collections:||Published Articles, Dept. of Biochemistry|
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