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Title: Sealed with a Kiz: How Plk1 ensures spindle pole integrity.
Authors: Fry, AM
Baxter, JE
First Published: Oct-2006
Citation: DEV CELL, 2006, 11 (4), pp. 431-432
Abstract: The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of Kiz ensures the integrity of spindle poles in the face of severe pulling forces exerted by the chromosome-attached spindle microtubules.
DOI Link: 10.1016/j.devcel.2006.09.012
ISSN: 1534-5807
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Biochemistry

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