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Title: Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor.
Authors: Cruse, G
Yang, W
Duffy, SM
Chachi, L
Leyland, M
Amrani, Y
Bradding, P
First Published: Jan-2010
Citation: J ALLERGY CLIN IMMUNOL, 2010, 125 (1), pp. 257-63.e1-5-257-63.e1-5
Abstract: Mast cells contribute to the pathophysiology of asthma with the sustained release of both preformed and newly generated mediators in response to allergens and other diverse stimuli. Stem cell factor (SCF) is the key human mast cell growth factor, but also primes mast cells for mediator release. SCF expression is markedly increased in asthmatic airways. Short-acting beta(2)-adrenoceptor drugs such as albuterol inhibit human lung mast cell (HLMC) degranulation in vitro in the absence of SCF, but their effect in the presence of SCF is not known.
DOI Link: 10.1016/j.jaci.2009.08.020
eISSN: 1097-6825
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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