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dc.contributor.authorWasmuth, J.-
dc.contributor.authorSchmid, Ralf-
dc.contributor.authorHedley, A.-
dc.contributor.authorBlaxter, M.-
dc.contributor.authorWasmuth, J.-
dc.contributor.authorSchmid, Ralf-
dc.identifier.citationPLoS Neglected Tropical Diseases, 2008, 2 (7)-
dc.description.abstractBackground The phylum Nematoda is biologically diverse, including parasites of plants and animals as well as free-living taxa. Underpinning this diversity will be commensurate diversity in expressed genes, including gene sets associated specifically with evolution of parasitism. Methods and Findings Here we have analyzed the extensive expressed sequence tag data (available for 37 nematode species, most of which are parasites) and define over 120,000 distinct putative genes from which we have derived robust protein translations. Combined with the complete proteomes of Caenorhabditis elegans and Caenorhabditis briggsae, these proteins have been grouped into 65,000 protein families that in turn contain 40,000 distinct protein domains. We have mapped the occurrence of domains and families across the Nematoda and compared the nematode data to that available for other phyla. Gene loss is common, and in particular we identify nearly 5,000 genes that may have been lost from the lineage leading to the model nematode C. elegans. We find a preponderance of novelty, including 56,000 nematode-restricted protein families and 26,000 nematode-restricted domains. Mapping of the latest time-of-origin of these new families and domains across the nematode phylogeny revealed ongoing evolution of novelty. A number of genes from parasitic species had signatures of horizontal transfer from their host organisms, and parasitic species had a greater proportion of novel, secreted proteins than did free-living ones. Conclusions These classes of genes may underpin parasitic phenotypes, and thus may be targets for development of effective control measures.-
dc.description.sponsorshipThis work is funded by a studentship from the Biotechnology and Biological Sciences Research Council, UK and CASE (AstraZeneca UK, Brixham Environmental Laboratory) to JW. RS and AH were supported by Natural Environment Research Council, UK as part of the Environmental Genomics Thematic Data Centre.-
dc.publisherPublic Library of Science-
dc.rightsCopyright: 2008 Wasmuth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.subjectProtein domains-
dc.subjectCaenorhabditis elegans-
dc.subjectGenome evolution-
dc.subjectGenomic databases-
dc.subjectPlant genomics-
dc.subjectSignal peptides-
dc.titleOn the extent and origins of genic novelty in the phylum nematoda-
dc.typeJournal Article-
Appears in Collections:Published Articles, Dept. of Biochemistry

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