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Title: The airway smooth muscle CCR3/CCL11 axis is inhibited by mast cells.
Authors: Saunders, R
Sutcliffe, A
Woodman, L
Kaur, D
Siddiqui, S
Okayama, Y
Wardlaw, A
Bradding, P
Brightling, C
First Published: Sep-2008
Citation: ALLERGY, 2008, 63 (9), pp. 1148-1155
Abstract: Airway smooth muscle hyperplasia is a feature of asthma, and increases with disease severity. CCR3-mediated recruitment of airway smooth muscle progenitors towards the airway smooth muscle bundle has been proposed as one possible mechanism involved in airway smooth muscle hyperplasia. Mast cells are microlocalized to the airway smooth muscle bundle and whether mast cells influence CCR3-mediated migration is uncertain.
DOI Link: 10.1111/j.1398-9995.2008.01684.x
eISSN: 1398-9995
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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