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Title: Resuscitation-promoting factors reveal an occult population of tubercle Bacilli in Sputum.
Authors: Mukamolova, GV
Turapov, O
Malkin, J
Woltmann, G
Barer, MR
First Published: 15-Jan-2010
Citation: AM J RESPIR CRIT CARE MED, 2010, 181 (2), pp. 174-180
Abstract: Resuscitation-promoting factors (Rpfs) are a family of secreted proteins produced by Mycobacterium tuberculosis (Mtb) that stimulate mycobacterial growth. Although mouse infection studies show that they support bacterial survival and disease reactivation, it is currently unknown whether Rpfs influence human infection. We hypothesized that tuberculous sputum might include a population of Rpf-dependent Mtb cells.
DOI Link: 10.1164/rccm.200905-0661OC
eISSN: 1535-4970
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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