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Title: Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells.
Authors: Al-Rasheed, NM
Meakin, F
Royal, EL
Lewington, AJ
Brown, J
Willars, GB
Brunskill, NJ
First Published: Jun-2004
Citation: DIABETOLOGIA, 2004, 47 (6), pp. 987-997
Abstract: Proinsulin C-peptide is generally believed to be inert without any appreciable biological functions. However, it has been shown to modulate a variety of cellular processes important in the pathophysiology of diabetic complications. We therefore investigated the ability of C-peptide to stimulate intracellular signalling pathways in kidney proximal tubular cells, the altered activation of which may possibly be related to the development of diabetic nephropathy.
DOI Link: 10.1007/s00125-004-1404-9
ISSN: 0012-186X
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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