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Title: Pirfenidone inhibits early myointimal proliferation but has no effect on late lesion size in rats.
Authors: Waller, JR
Murphy, GJ
Bicknell, GR
Sandford, R
Margolin, SB
Nicholson, ML
First Published: Mar-2002
Citation: EUR J VASC ENDOVASC SURG, 2002, 23 (3), pp. 234-240
Abstract: intimal hyperplasia is mediated by smooth muscle cell proliferation, migration and deposition of extracellular matrix. The anti-fibrotic agent pirfenidone has been shown to inhibit pro-fibrotic growth factors in non-vascular inflammatory models. This study investigated the effect of the novel anti-fibrotic agent pirfenidone on the development of neointima.
DOI Link: 10.1053/ejvs.2001.1574
ISSN: 1078-5884
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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