Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/14976
Title: Intracellular signalling by C-peptide.
Authors: Hills, Claire E.
Brunskill, Nigel J.
First Published: 2008
Publisher: Hindawi Publishing Corporation
Citation: Experimental Diabetes Research, Volume 2008 (2008), Article ID 635158
Abstract: C-peptide, a cleavage product of the proinsulin molecule, has long been regarded as biologically inert, serving merely as a surrogate marker for insulin release. Recent findings demonstrate both a physiological and protective role of C-peptide when administered to individuals with type I diabetes. Data indicate that C-peptide appears to bind in nanomolar concentrations to a cell surface receptor which is most likely to be G-protein coupled. Binding of C-peptide initiates multiple cellular effects, evoking a rise in intracellular calcium, increased PI-3-kinase activity, stimulation of the Na[superscript +]/K[superscript +] ATPase, increased eNOS transcription, and activation of the MAPK signalling pathway. These cell signalling effects have been studied in multiple cell types from multiple tissues. Overall these observations raise the possibility that C-peptide may serve as a potential therapeutic agent for the treatment or prevention of long-term complications associated with diabetes.
DOI Link: 10.1155/2008/635158
ISSN: 1687-5214
eISSN: 1687-5303
Links: http://hdl.handle.net/2381/14976
http://www.hindawi.com/journals/jdr/2008/635158/
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2008 C. E. Hills and N. J. Brunskill. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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