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Title: Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains.
Authors: Gingles, NA
Alexander, JE
Kadioglu, A
Andrew, PW
Kerr, A
Mitchell, TJ
Hopes, E
Denny, P
Brown, S
Jones, HB
Little, S
Booth, GC
McPheat, WL
First Published: Jan-2001
Citation: INFECT IMMUN, 2001, 69 (1), pp. 426-434
Abstract: From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.
DOI Link: 10.1128/IAI.69.1.426-434.2001
ISSN: 0019-9567
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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