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Title: Evaluation of molecular-Beacon, TaqMan, and fluorescence resonance energy transfer probes for detection of antibiotic resistance-conferring single nucleotide polymorphisms in mixed Mycobacterium tuberculosis DNA extracts.
Authors: Yesilkaya, H
Meacci, F
Niemann, S
Hillemann, D
Rüsch-Gerdes, S
LONG DRUG Study Group
Barer, MR
Andrew, PW
Oggioni, MR
First Published: Oct-2006
Citation: J CLIN MICROBIOL, 2006, 44 (10), pp. 3826-3829
Abstract: The ability of fluorescence resonance energy transfer, molecular-beacon, and TaqMan probes to detect single nucleotide polymorphism (SNP) in the presence of a wild-type allele was evaluated using drug resistance-conferring SNPs in mixed Mycobacterium tuberculosis DNA. It was found that both the absolute quantity and the ratio of alleles determine the detection sensitivity of the probe systems.
DOI Link: 10.1128/JCM.00225-06
ISSN: 0095-1137
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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