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Title: Mesangial matrix-activated monocytes express functional scavenger receptors and accumulate intracellular lipid.
Authors: Rahman, EU
Ruan, XZ
Chana, RS
Brunskill, NJ
Gaya, J
Powis, SH
Varghese, Z
Moorhead, JF
Wheeler, DC
First Published: Jun-2008
Citation: NEPHROL DIAL TRANSPLANT, 2008, 23 (6), pp. 1876-1885
Abstract: Monocyte recruitment into the mesangium and foam cell formation are recognized features of glomerular injury. External signals encountered by infiltrating mononuclear cells may determine their behaviour and thereby potentially influence disease outcome. Having previously demonstrated that monocytes are activated by exposure to matrix secreted by mesangial cells, we set out to determine whether matrix activation of monocytes led to expression of a macrophage phenotype.
DOI Link: 10.1093/ndt/gfm901
eISSN: 1460-2385
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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