Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/15213
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dc.contributor.authorShao, Y.-
dc.contributor.authorHarrison, E. M.-
dc.contributor.authorBi, D.-
dc.contributor.authorTai, C.-
dc.contributor.authorHe, X.-
dc.contributor.authorOu, H. Y.-
dc.contributor.authorRajakumar, K.-
dc.contributor.authorDeng, Z.-
dc.date.accessioned2012-10-24T08:59:28Z-
dc.date.available2012-10-24T08:59:28Z-
dc.date.issued2010-10-06-
dc.identifier.citationNucleic Acids Research, 2011, 39 (Database issue), pp. D606-D611-
dc.identifier.issn0305-1048-
dc.identifier.urihttp://hdl.handle.net/2381/15213-
dc.identifier.urihttp://nar.oxfordjournals.org/content/39/suppl_1/D606-
dc.description.abstractTADB (http://bioinfo-mml.sjtu.edu.cn/TADB/) is an integrated database that provides comprehensive information about Type 2 toxin-antitoxin (TA) loci, genetic features that are richly distributed throughout bacterial and archaeal genomes. Two-gene and much less frequently three-gene Type 2 TA loci code for cognate partners that have been hypothesized or demonstrated to play key roles in stress response, bacterial physiology and stabilization of horizontally acquired genetic elements. TADB offers a unique compilation of both predicted and experimentally supported Type 2 TA loci-relevant data and currently contains 10,753 Type 2 TA gene pairs identified within 1240 prokaryotic genomes, and details of over 240 directly relevant scientific publications. A broad range of similarity search, sequence alignment, genome context browser and phylogenetic tools are readily accessible via TADB. We propose that TADB will facilitate efficient, multi-disciplinary and innovative exploration of the bacteria and archaea Type 2 TA space, better defining presently recognized TA-related phenomena and potentially even leading to yet-to-be envisaged frontiers. The TADB database, envisaged as a one-stop shop for Type 2 TA-related research, will be maintained, updated and improved regularly to ensure its ongoing maximum utility to the research community.-
dc.language.isoeng-
dc.publisherOxford University Press-
dc.rights© The Author(s) 2010. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.sourcePubMed-
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/-
dc.subjectArchaea-
dc.subjectArchaeal Proteins-
dc.subjectBacteria-
dc.subjectBacterial Proteins-
dc.subjectBacterial Toxins-
dc.subjectDatabases-
dc.subjectGenetic-
dc.subjectGenetic Loci-
dc.subjectGenome-
dc.subjectArchaeal-
dc.subjectGenome-
dc.subjectBacterial-
dc.subjectInternet-
dc.subjectToxins-
dc.subjectBiological-
dc.titleTADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea.-
dc.typeJournal Article-
dc.identifier.doi10.1093/nar/gkq908-
dc.identifier.eissn1362-4962-
dc.identifier.piigkq908-
dc.description.statusPeer-reviewed-
dc.description.versionPublisher Version-
dc.description.irispid15777-
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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