Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/15237
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dc.contributor.authorOu, H. Y.-
dc.contributor.authorHe, X.-
dc.contributor.authorShao, Y.-
dc.contributor.authorTai, C.-
dc.contributor.authorRajakumar, K.-
dc.contributor.authorDeng, Z.-
dc.date.accessioned2012-10-24T08:59:29Z-
dc.date.available2012-10-24T08:59:29Z-
dc.date.issued2009-04-09-
dc.identifier.citationPLOS ONE, 2009, 4 (4), p. e5132-
dc.identifier.urihttp://hdl.handle.net/2381/15237-
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005132-
dc.description.abstractThe Dnd DNA degradation phenotype was first observed during electrophoresis of genomic DNA from Streptomyces lividans more than 20 years ago. It was subsequently shown to be governed by the five-gene dnd cluster. Similar gene clusters have now been found to be widespread among many other distantly related bacteria. Recently the dnd cluster was shown to mediate the incorporation of sulphur into the DNA backbone via a sequence-selective, stereo-specific phosphorothioate modification in Escherichia coli B7A. Intriguingly, to date all identified dnd clusters lie within mobile genetic elements, the vast majority in laterally transferred genomic islands.-
dc.language.isoeng-
dc.publisherPublic Library of Science-
dc.rightsCopyright © 2009 Ou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.sourcePubMed-
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/-
dc.subjectAmino Acid Sequence-
dc.subjectBacteria-
dc.subjectBase Sequence-
dc.subjectComputational Biology-
dc.subjectDNA-
dc.subjectDatabases-
dc.subjectGenetic-
dc.subjectGene Transfer-
dc.subjectHorizontal-
dc.subjectGenes-
dc.subjectArchaeal-
dc.subjectGenes-
dc.subjectBacterial-
dc.subjectGenomic Islands-
dc.subjectHumans-
dc.subjectInternet-
dc.subjectMolecular Sequence Data-
dc.subjectMultigene Family-
dc.subjectPhosphates-
dc.subjectPhosphorothioate Oligonucleotides-
dc.subjectPhylogeny-
dc.subjectSequence Alignment-
dc.subjectSoftware-
dc.subjectUser-Computer Interface-
dc.titledndDB: a database focused on phosphorothioation of the DNA backbone.-
dc.typeJournal Article-
dc.identifier.doi10.1371/journal.pone.0005132-
dc.identifier.eissn1932-6203-
dc.description.statusPeer-reviewed-
dc.description.versionPublisher Version-
dc.description.irispid15821-
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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