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Title: Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathways.
Authors: Tliba, O
Amrani, Y
First Published: 1-Jan-2008
Citation: PROC AM THORAC SOC, 2008, 5 (1), pp. 106-112
Abstract: The present article will describe the potential role of airway smooth muscle (ASM) in mediating both deleterious/beneficial effects of interferons (IFNs) in asthma. First described as beneficial in treating the main features of asthma, the interplay between IFNs and ASM could explain their deleterious actions recently described in a number of different studies. Through multiple mechanisms, including the suppression of steroid action, the synergistic pro-inflammatory actions when combined with other cytokines, and the modulation of calcium metabolism, IFNs are now seen as critical mediators in the pathogenesis of asthma.
DOI Link: 10.1513/pats.200705-060VS
ISSN: 1546-3222
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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