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Title: Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway.
Authors: Thomas, RA
Norman, JC
Huynh, TT
Williams, B
Bolton, SJ
Wardlaw, AJ
First Published: Sep-2006
Citation: RESPIR MED, 2006, 100 (9), pp. 1588-1597
Abstract: In vivo, the airway epithelium stretches and relaxes with each respiratory cycle, but little is known about the effect this pattern of elongation and relaxation has on bronchial epithelial cells. We have used a model of cell deformation to measure the effect of stretch on inflammatory cytokine release by the BEAS 2B cell line, and to examine the method of mechanotransduction in these cells.
DOI Link: 10.1016/j.rmed.2005.12.008
ISSN: 0954-6111
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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