Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/15258
Title: Mannitol and AMP do not induce bronchoconstriction in eosinophilic bronchitis: further evidence for dissociation between airway inflammation and bronchial hyperresponsiveness.
Authors: Singapuri, A
McKenna, S
Brightling, CE
Bradding, P
First Published: Apr-2010
Citation: RESPIROLOGY, 2010, 15 (3), pp. 510-515
Abstract: Eosinophilic bronchitis (EB) shares many pathological features with asthma. However, patients with EB do not develop the characteristic physiological abnormalities of asthma: variable airflow obstruction and bronchial hyperresponsiveness (BHR) to a direct bronchial challenge with methacholine. Indirect bronchial challenges with AMP and mannitol are dependent on the presence of airway inflammation, and positive in 10% of asthmatic subjects who have a negative response to methacholine. We have therefore investigated whether subjects with EB are responsive to indirect airway challenge with AMP and mannitol.
DOI Link: 10.1111/j.1440-1843.2010.01712.x
eISSN: 1440-1843
Links: http://hdl.handle.net/2381/15258
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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