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Title: Functional KCa3.1 K+ channels are required for human lung mast cell migration.
Authors: Cruse, G
Duffy, SM
Brightling, CE
Bradding, P
First Published: Oct-2006
Citation: THORAX, 2006, 61 (10), pp. 880-885
Abstract: Mast cell recruitment and activation are critical for the initiation and progression of inflammation and fibrosis. Mast cells infiltrate specific structures in many diseased tissues such as the airway smooth muscle (ASM) in asthma. This microlocalisation of mast cells is likely to be key to disease pathogenesis. Human lung mast cells (HLMC) express the Ca2+ activated K+ channel K(Ca)3.1 which modulates mediator release, and is proposed to facilitate the retraction of the cell body during migration of several cell types. A study was undertaken to test the hypothesis that blockade of K(Ca)3.1 would attenuate HLMC proliferation and migration.
DOI Link: 10.1136/thx.2006.060319
ISSN: 0040-6376
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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