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|Title:||Functional KCa3.1 K+ channels are required for human lung mast cell migration.|
|Citation:||THORAX, 2006, 61 (10), pp. 880-885|
|Abstract:||Mast cell recruitment and activation are critical for the initiation and progression of inflammation and fibrosis. Mast cells infiltrate specific structures in many diseased tissues such as the airway smooth muscle (ASM) in asthma. This microlocalisation of mast cells is likely to be key to disease pathogenesis. Human lung mast cells (HLMC) express the Ca2+ activated K+ channel K(Ca)3.1 which modulates mediator release, and is proposed to facilitate the retraction of the cell body during migration of several cell types. A study was undertaken to test the hypothesis that blockade of K(Ca)3.1 would attenuate HLMC proliferation and migration.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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