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Title: Protocol biopsy of the stable renal transplant: a multicenter study of methods and complication rates.
Authors: Furness, PN
Philpott, CM
Chorbadjian, MT
Nicholson, ML
Bosmans, JL
Corthouts, BL
Bogers, JJ
Schwarz, A
Gwinner, W
Haller, H
Mengel, M
Seron, D
Moreso, F
Cañas, C
First Published: 27-Sep-2003
Citation: TRANSPLANTATION, 2003, 76 (6), pp. 969-973
Abstract: Clinical trials in renal transplantation must use surrogate markers of long-term graft survival if conclusions are to be drawn at acceptable speed and cost. Morphologic changes in transplant biopsies provide the earliest available evidence of damage, and "protocol" biopsies from stable grafts can be used to reduce the number of patients needed in clinical trials. This approach has been inhibited by concerns over safety, but the risk of biopsy of a stable kidney, with no active inflammation or acute functional impairment, has never been formally estimated.
DOI Link: 10.1097/01.TP.0000082542.99416.11
ISSN: 0041-1337
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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